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histone h1 การใช้

ประโยคมือถือ
  • CDK3 can phosphorylate histone H1 and interacts with an unknown type of cyclin.
  • All core histones and linker histone H1 are ADP-ribosylated following DNA damage.
  • Histone H1 differs strongly from the core histones.
  • The nucleosome core particle, together with histone H1, is known as a chromatosome.
  • Histone H1 locks the nucleosome complex together, and it is the last protein to bind in the complex.
  • This gene encodes a histone H1 binding protein that is involved in transporting histones into the nucleus of dividing cells.
  • Histone H1, which is not part of the binding histones, tightens the DNA bound to the eight protein complex.
  • Experiments in " Xenopus " egg extracts have also implicated linker Histone H1 as an important regulator of mitotic chromosome compaction.
  • Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3.
  • It is believed that CHD8 also recruits the linker histone H1 and causes the repression of ?-catenin and p53 target genes.
  • The discovery of the H5 histone appears to date back to the 1970s, and it is now considered an isoform of Histone H1.
  • Cytoplasmic factors appear to be necessary for the dynamic exchange of histone H1 on chromatin, but these have yet to be specifically identified.
  • Evolutionary tree of eukaryotes showing in brackets the number of known linker histone H1 variants in a given species ( see original data in)
  • In chromatin neighboring nucleosomes are separated by the linker DNA and in many cases also by the linker histone H1 as well as non-histone proteins.
  • HMGNs are non-histone proteins, which associate with nucleosomes to control transcription by altering the interaction of histone H1 with nucleosomes to maintain a decondensed chromatin structure.
  • The linker histone H1 binds the nucleosome at the entry and exit sites of the DNA, thus locking the DNA into place and allowing the formation of higher order structure.
  • Nuclease digestion and DNA footprinting experiments suggest that the globular domain of histone H1 localizes near the nucleosome dyad, where it protects approximately 15-30 base pairs of additional DNA.
  • "' Histone H1 "'is one of the five main histone protein families which are components of chromatin in conserved, it is nevertheless the most variable histone in sequence across species.
  • Histone H1 was shown to stabilize the structure by winding two turns of linker DNA around the octamer while HMGB1 destabilized the nucleosome by bending adjacent DNA . NMR spectroscopy was again used to show that H1 binds to the acidic tail of HMGB1 via its basic C-terminus, thus halting the HMGB1-DNA interaction.